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The IncP-1 plasmid backbone adapts to different host bacterial species and evolves through homologous recombination.

Peter Norberg ; Maria Bergström ; Vinay Jethava (Institutionen för data- och informationsteknik, Datavetenskap (Chalmers)) ; Devdatt Dubhashi (Institutionen för data- och informationsteknik, Datavetenskap (Chalmers)) ; Malte Hermansson
Nature communications (2041-1723). Vol. 2 (2011), p. 268.
[Artikel, refereegranskad vetenskaplig]

Plasmids are important members of the bacterial mobile gene pool, and are among the most important contributors to horizontal gene transfer between bacteria. They typically harbour a wide spectrum of host beneficial traits, such as antibiotic resistance, inserted into their backbones. Although these inserted elements have drawn considerable interest, evolutionary information about the plasmid backbones, which encode plasmid related traits, is sparse. Here we analyse 25 complete backbone genomes from the broad-host-range IncP-1 plasmid family. Phylogenetic analysis reveals seven clades, in which two plasmids that we isolated from a marine biofilm represent a novel clade. We also found that homologous recombination is a prominent feature of the plasmid backbone evolution. Analysis of genomic signatures indicates that the plasmids have adapted to different host bacterial species. Globally circulating IncP-1 plasmids hence contain mosaic structures of segments derived from several parental plasmids that have evolved in, and adapted to, different, phylogenetically very distant host bacterial species.

Nyckelord: Bacteria, classification, genetics, DNA Transposable Elements, Evolution, Molecular, Molecular Sequence Data, Phylogeny, Plasmids, genetics, Recombination, Genetic



Denna post skapades 2013-01-08.
CPL Pubid: 169522

 

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Institutioner (Chalmers)

Institutionen för cell- och molekylärbiologi, mikrobiologi (1994-2011)
Institutionen för biomedicin, avdelningen för infektionssjukdomar (GU)
Institutionen för data- och informationsteknik, Datavetenskap (Chalmers)

Ämnesområden

Mikrobiologi

Chalmers infrastruktur