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Systems biology of yeast: enabling technology for development of cell factories for production of advanced biofuels

Bouke Wim de Jong (Institutionen för kemi- och bioteknik, Systembiologi) ; Verena Siewers (Institutionen för kemi- och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi)
Current Opinion in Biotechnology (0958-1669). Vol. 23 (2012), 4, p. 624-630.
[Artikel, refereegranskad vetenskaplig]

Transportation fuels will gradually shift from oil based fuels towards alternative fuel resources like biofuels. Current bioethanol and biodiesel can, however, not cover the increasing demand for biofuels and there is therefore a need for advanced biofuels with superior fuel properties. Novel cell factories will provide a production platform for advanced biofuels. However, deep cellular understanding is required for improvement of current biofuel cell factories. Fast screening and analysis (-omics) methods and metabolome-wide mathematical models are promising techniques. An integrated systems approach of these techniques drives diversity and quantity of several new biofuel compounds. This review will cover the recent technological developments that support improvement of the advanced biofuels 1-butanol, biodiesels and jetfuels.

Nyckelord: escherichia-coli, saccharomyces-cerevisiae, mass-spectrometry, high-throughput, quantitative metabolomics, butanol production, flux, analysis, acetobutylicum, metabolism, expression

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Denna post skapades 2012-10-25. Senast ändrad 2016-10-21.
CPL Pubid: 165088


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)


Biologiska vetenskaper

Chalmers infrastruktur