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Aspergilli: Systems biology and industrial applications

Christoph Knuf (Institutionen för kemi- och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi)
Biotechnology Journal (1860-6768). Vol. 7 (2012), 9,
[Artikel, refereegranskad vetenskaplig]

Aspergilli are widely used as cell factories for the production of food ingredients, enzymes and antibiotics. Traditionally, improvement of these cell factories has been done using classical methods, that is, random mutagenesis and screening; however, advances in methods for performing directed genetic modifications has enabled the use of metabolic engineering strategies. Genome sequencing of Aspergilli was originally trailing behind developments in the field of bacteria and yeasts, but with the recent availability of genome sequences for several industrially relevant Aspergilli, it has become possible to implement systems biology tools to advance metabolic engineering. These tools include genome-wide transcription analysis and genome-scale metabolic models. Herein, we review achievements in the field and highlight the impact of Aspergillus systems biology on industrial biotechnology.

Nyckelord: Aspergillus, Industrial biotechnology, Metabolic engineering, Systems biology, metabolic control analysis, citric-acid accumulation, carbohydrate-metabolism, modeling approach, steady-state, niger, genome, fluxes, proteomics, nidulans

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Denna post skapades 2012-10-25. Senast ändrad 2014-10-27.
CPL Pubid: 165069


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)


Biologiska vetenskaper

Chalmers infrastruktur

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Denna publikation ingår i:

Malic acid production by Aspergillus oryzae



Denna publikation är ett resultat av följande projekt:

Industrial Systems Biology of Yeast and A. oryzae (INSYSBIO) (EC/FP7/247013)