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In vivo biomechanical stability of osseointegrating mesoporous TiO2 implants

Johan Karlsson (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; Ryo Jimbo ; Hoda Mashadi Fathali (Institutionen för kemi- och bioteknik, Analytisk kemi) ; Humberto Osvaldo Schwartz-Filho ; Mariko Hayashi ; Mats Halvarsson (Institutionen för teknisk fysik, Materialens mikrostruktur ) ; Ann Wennerberg ; Martin Andersson (Institutionen för kemi- och bioteknik, Teknisk ytkemi)
Acta Biomaterialia (1742-7061). Vol. 8 (2012), 12, p. 4438-4446.
[Artikel, refereegranskad vetenskaplig]

Mesoporous materials are of high interest as implant coatings to receive an enhanced osseointegration. In this study, titanium implants coated with mesoporous TiO(2) thin films have been evaluated both in vitro and in vivo. Material characterization showed that, with partly crystalline TiO(2) (anatase), long-range-ordered hydrophilic mesoporous thin films with a pore size of 6nm were obtained. Evaluation of the mechanical resistance showed that the films were robust enough to withstand the standard implantation procedure. In vitro apatite formation was studied using simulated body fluids, showing that the pores are accessible for ions and that formation of apatite was increased due to the presence of the mesopores. An in vivo study using a rabbit model was executed in which the removal torque and histomorphometry were evaluated. The results show that the biomechanical stability of the TiO(2) coating was unaffected by the presence of mesopores and that osseointegration was achieved without any signs of inflammation.

Nyckelord: Osseointegration, Implant, Mesoporous TiO2, Nanotopography, Biomechanical stability



Denna post skapades 2012-10-24. Senast ändrad 2016-08-19.
CPL Pubid: 165046

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)
Institutionen för kemi- och bioteknik, Analytisk kemi (2006-2014)
Institutionen för teknisk fysik, Materialens mikrostruktur (2012-2015)

Ämnesområden

Biomaterial

Chalmers infrastruktur