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Does ketoprofen or diclofenac pose the lowest risk to fish?

Filip Cuklev ; J. Fick ; Marija Cvijovic (Institutionen för neurovetenskap och fysiologi ; Institutionen för matematiska vetenskaper, matematik) ; Erik Kristiansson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Lars Förlin ; D. G. Joakim Larsson
Journal of Hazardous Materials (0304-3894). Vol. 229-230 (2012), p. 100-106.
[Artikel, refereegranskad vetenskaplig]

Ketoprofen and diclofenac are non-steroidal anti-inflammatory drugs (NSAIDs) often used for similar indications, and both are frequently found in surface waters. Diclofenac affects organ histology and gene expression in fish at around 1 mu g/L. Here, we exposed rainbow trout to ketoprofen (1, 10 and 100 mu g/L) to investigate if this alternative causes less risk for pharmacological responses in fish. The bioconcentration factor from water to fish blood plasma was <0.05(4 for diclofenac based on previous studies). Ketoprofen only reached up to 0.6 parts per thousand of the human therapeutic plasma concentration, thus the probability of target-related effects was estimated to be fairly low. Accordingly, a comprehensive analysis of hepatic gene expression revealed no consistent responses. In some contrast, trout exposed to undiluted, treated sewage effluents bioconcentrated ketoprofen and other NSAIDs much more efficiently, according to a meta-analysis of recent studies. Neither of the setups is however an ideal representation of the field situation. If a controlled exposure system with a single chemical in pure water is a reasonable representation of the environment, then the use of ketoprofen is likely to pose a lower risk for wild fish than diclofenac, but if bioconcentration factors from effluent-exposed fish are applied, the risks may be more similar.

Nyckelord: Ketoprofen, NSAID, Fish, Bioconcentration, Gene expression, trout oncorhynchus-mykiss, hepatic gene-expression, rainbow-trout, human, pharmaceuticals, sewage effluents, blood-plasma, bioconcentration, bioaccumulation, drugs, liver

Denna post skapades 2012-09-20. Senast ändrad 2017-07-03.
CPL Pubid: 163624


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Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi (GU)
Institutionen för neurovetenskap och fysiologi (GU)
Institutionen för matematiska vetenskaper, matematik (2005-2016)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för biologi och miljövetenskap (GU)


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