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Does ketoprofen or diclofenac pose the lowest risk to fish?

Filip Cuklev ; J. Fick ; Marija Cvijovic (Institutionen för matematiska vetenskaper ; Institutionen för neurovetenskap och fysiologi) ; Erik Kristiansson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Lars Förlin ; D. G. Joakim Larsson
Journal of Hazardous Materials (0304-3894). Vol. 229-230 (2012), p. 100-106.
[Artikel, refereegranskad vetenskaplig]

Ketoprofen and diclofenac are non-steroidal anti-inflammatory drugs (NSAIDs) often used for similar indications, and both are frequently found in surface waters. Diclofenac affects organ histology and gene expression in fish at around 1 mu g/L. Here, we exposed rainbow trout to ketoprofen (1, 10 and 100 mu g/L) to investigate if this alternative causes less risk for pharmacological responses in fish. The bioconcentration factor from water to fish blood plasma was <0.05(4 for diclofenac based on previous studies). Ketoprofen only reached up to 0.6 parts per thousand of the human therapeutic plasma concentration, thus the probability of target-related effects was estimated to be fairly low. Accordingly, a comprehensive analysis of hepatic gene expression revealed no consistent responses. In some contrast, trout exposed to undiluted, treated sewage effluents bioconcentrated ketoprofen and other NSAIDs much more efficiently, according to a meta-analysis of recent studies. Neither of the setups is however an ideal representation of the field situation. If a controlled exposure system with a single chemical in pure water is a reasonable representation of the environment, then the use of ketoprofen is likely to pose a lower risk for wild fish than diclofenac, but if bioconcentration factors from effluent-exposed fish are applied, the risks may be more similar.

Nyckelord: Ketoprofen, NSAID, Fish, Bioconcentration, Gene expression, trout oncorhynchus-mykiss, hepatic gene-expression, rainbow-trout, human, pharmaceuticals, sewage effluents, blood-plasma, bioconcentration, bioaccumulation, drugs, liver



Denna post skapades 2012-09-20. Senast ändrad 2013-01-21.
CPL Pubid: 163624

 

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Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi (GU)
Institutionen för matematiska vetenskaperInstitutionen för matematiska vetenskaper (GU)
Institutionen för neurovetenskap och fysiologi (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för biologi och miljövetenskap (GU)

Ämnesområden

Annan medicin och hälsovetenskap

Chalmers infrastruktur