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Graphene Oxide and Lipid Membranes: Interactions and Nanocomposite Structures

Rickard Frost (Institutionen för teknisk fysik, Biologisk fysik) ; Gustav Edman Jönsson (Institutionen för teknisk fysik, Kemisk fysik) ; Dinko Chakarov (Institutionen för teknisk fysik, Kemisk fysik) ; Sofia Svedhem (Institutionen för teknisk fysik, Biologisk fysik) ; Bengt Kasemo (Institutionen för teknisk fysik, Kemisk fysik)
Nano Letters (1530-6984). Vol. 12 (2012), 7, p. 3356-3362.
[Artikel, refereegranskad vetenskaplig]

We have investigated the interaction between graphene oxide and lipid membranes, using both supported lipid membranes and supported liposomes. Also, the reverse situation, where a surface coated with graphene oxide was exposed to liposomes in solution, was studied. We discovered graphene oxide-induced rupture of preadsorbed liposomes and the formation of a nanocomposite, bio-nonbio multilayer structure, consisting of alternating graphene oxide monolayers and lipid membranes. The assembly process was monitored in real time by two complementary surface analytical techniques (the quartz crystal microbalance with dissipation monitoring technique (QCM-D) and dual polarization interferometry (DPI)), and the formed structures were imaged with atomic force microscopy (AFM). From a basic science point of view, the results point toward the importance of electrostatic interactions between graphene oxide and lipid headgroups. Implications from a more practical point of view concern structure activity relationship for biological health/safety aspects of graphene oxide and the potential of the nanocomposite, multilayer structure as scaffolds for advanced biomolecular functions and sensing applications.

Nyckelord: Graphene oxide, lipid membrane, QCM-D, DPI, AFM, layer-by-layer, vesicle adsorption, bilayer formation, fluid, tio2, sio2, size, au

Denna post skapades 2012-08-16. Senast ändrad 2015-02-11.
CPL Pubid: 161852


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Institutioner (Chalmers)

Institutionen för teknisk fysik, Biologisk fysik (2007-2015)
Institutionen för teknisk fysik, Kemisk fysik (1900-2015)



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