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Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome

C. Ahlgren ; Anders Odén (Institutionen för matematiska vetenskaper, matematisk statistik) ; T. Bergstrom ; J. Lycke
Journal of Neuroimmunology (0165-5728). Vol. 247 (2012), 1-2, p. 70-74.
[Artikel, refereegranskad vetenskaplig]

In general, measles virus (MV) immunoglobulin G (IgG) antibody titres decline over time. However, we found that serum and CSF MV antibody titres increased with age (slope=0.038, p<0.001 and slope=0.022, p=0.008), respectively, and disease duration (slope=0.031, p=0.002 and slope=0.032, p=0.005), respectively, in patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS). The age dependency of serum antibody levels differed between patients and controls (slope=0.038 versus -0.004, p<0.001). The increasing MV antibody litres over time in MS/CIS patients support a general nonspecific stimulation of B cells and plasma cells that is not confined only to the CNS/CSF compartment.

Nyckelord: Multiple sclerosis, Epidemiology, Measles virus antibodies, CSF, epstein-barr-virus, b-cell follicles, cerebrospinal-fluid, immune-response, matched controls, rubella, inflammation, infection, rituximab, vaccine

Denna post skapades 2012-06-28.
CPL Pubid: 159752


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