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Osmotic-driven mass transport of water: Impact on the adhesiveness of hydrophilic polymers

Författare och institution:
Annika Borde (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi); Anna Bergstrand (Institutionen för kemi- och bioteknik); Cecilia Gunnarsson (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi); Anette Larsson (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi)
Publicerad i:
Journal of Colloid and Interface Science, 341 ( 2 ) s. 255-260
ISSN:
0021-9797
Publikationstyp:
Artikel, refereegranskad vetenskaplig
Publiceringsår:
2009
Språk:
engelska
Fulltextlänk:
Sammanfattning (abstract):
Adhesion is an important property for the functionality of many medical devices. One reason for the development of adhesive forces is dehydration caused by mass transport of water. Osmotic pressure is one main driving force for mass transport and the correlation between osmotic pressure and adhesive force has not been studied yet, which was the aim of the present study. A model system was used where a Carbopol tablet was lowered onto a 1% (w/w) agarose gel. The force required to detach the tablet (adhesive force) and the weight gain of the tablet (as a measure of transported water) were determined. Sodium chloride and mannitol were added to the agarose gel to decrease the osmotic pressure difference between the agarose gel and the partially hydrated Carbopol tablet. This resulted in a decrease of both mass transport and adhesive force. In addition, experiments with restricted water transport within the agarose gel were performed by preparing gels with different agarose concentrations. An increase of the agarose concentration resulted in decreased water transport and higher adhesive forces. Hence, the results confirmed our hypothesis that osmotic-driven mass transport and restricted mass transport of water correlate very well with the adhesive force.
Ämne (baseras på Högskoleverkets indelning av forskningsämnen):
NATURVETENSKAP ->
Kemi
MEDICIN OCH HÄLSOVETENSKAP ->
Medicinska grundvetenskaper ->
Farmaceutisk vetenskap ->
Övrig farmaci
Chalmers styrkeområden:
Materialvetenskap
Postens nummer:
159402
Ingår i post nr:
Posten skapad:
2012-06-25 11:29
Posten ändrad:
2013-10-29 15:25

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