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Design and characterization of a novel amphiphilic chitosan nanocapsule-based thermo-gelling biogel with sustained in vivo release of the hydrophilic anti-epilepsy drug ethosuximide

Meng-Hsuan Hsiao ; Mikael Larsson (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi ; SuMo Biomaterials) ; Anette Larsson (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi ; SuMo Biomaterials) ; Hanne Evenbratt (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi) ; Ying-Yu Chen ; You-Yin Chen ; Dean-Mo Liu
Journal of Controlled Release (0168-3659). Vol. 161 (2012), 3, p. 942-948.
[Artikel, refereegranskad vetenskaplig]

Thermo-gelling injectable nanogels, with no burst release of loaded drug, were prepared by a simple route by combining self assembled nanocapsules of amphiphilically modified chitosan with glycerophosphate di-sodium salt and glycerol. The potential as a depot drug delivery system was demonstrated in vivo through the therapeutic effect of ethosuximide (ESM) loaded nanogels, suppressing spike wave discharges (SWDs) in Long Evan rat model. Simultaneously clearance of gels from the site of administration was monitored non-invasively using MRI. The gel structure was characterized using TEM and SEM, confirming the gels to be an assembly of nanocapsules and using two-photon microscopy to visualize the network structure. In vitro drug release studies using ESM revealed that the nanogels exhibited extended, mostly Fickian release. Finally, all investigated formulations displayed excellent cytotoxicity data determined by MTT assay using human retinal pigmented epithelium cells. All presented properties are highly desirable for injectable depot gels for drug delivery.

Nyckelord: Amphiphilic chitosan, Drug delivery, Nano capsules, Thermo responsive, In vivo


The first two authors contributed equally to this work.



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Denna post skapades 2012-06-04. Senast ändrad 2016-09-06.
CPL Pubid: 158468

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Farmaceutisk teknologi (2005-2014)
SuMo Biomaterials

Ämnesområden

Materialvetenskap
Nanovetenskap och nanoteknik
Kemi
Galenisk farmaci
Kemi

Chalmers infrastruktur