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Metabolic Engineering of Saccharomyces cerevisiae: A Key Cell Factory Platform for Future Biorefineries

Kuk-Ki Hong (Institutionen för kemi- och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi)
Cellular and Molecular Life Sciences (1420-682X). (2012)
[Artikel, refereegranskad vetenskaplig]

Metabolic engineering is the enabling science of development of efficient cell factories for the production of fuels, chemicals, pharmaceuticals, and food ingredients through microbial fermentations. The yeast Saccharomyces cerevisiae is a key cell factory already used for the production of a wide range of industrial products, and here we review ongoing work, particularly in industry, on using this organism for the production of butanol, which can be used as biofuel, and isoprenoids, which can find a wide range of applications including as pharmaceuticals and as biodiesel. We also look into how engineering of yeast can lead to improved uptake of sugars that are present in biomass hydrolyzates, and hereby allow for utilization of biomass as feedstock in the production of fuels and chemicals employing S. cerevisiae. Finally, we discuss the perspectives of how technologies from systems biology and synthetic biology can be used to advance metabolic engineering of yeast.

Nyckelord: Metabolic engineering, Yeast Substrate range, Biobutanol, Isoprenoids, Industrial biotechnology

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Denna post skapades 2012-05-25. Senast ändrad 2014-10-27.
CPL Pubid: 158077


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)


Hållbar utveckling
Industriell bioteknik
Biokatalys och enzymteknik
Genteknik inkl. funktionsgenomik

Chalmers infrastruktur

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Denna publikation ingår i:

Advancing Metabolic Engineering through Combination of Systems Biology and Adaptive Evolution