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A generic 3D kinetic model of gene expression

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Central European Journal of Physics (1895-1082). Vol. 10 (2012), 2, p. 533-537.
[Artikel, övrig vetenskaplig]

Recent experiments show that mRNAs and proteins can be localized both in prokaryotic and eukaryotic cells. To describe such situations, I present a 3D mean-field kinetic model aimed primarily at gene expression in prokaryotic cells, including the formation of mRNA, its translation into protein, and slow diffusion of these species. Under steady-state conditions, the mRNA and protein spatial distribution is described by simple exponential functions. The protein concentration near the gene transcribed into mRNA is shown to depend on the protein and mRNA diffusion coefficients and degradation rate constants.

Nyckelord: subcellular processes, gene transcription, mRNA synthesis, mRNA, translation, mRNA and protein diffusion and degradation, subcellular-localization, bacterial-cells, messenger-rna, transcription, diffusion

Denna post skapades 2012-05-11.
CPL Pubid: 157532


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Institutionen för teknisk fysik, Kemisk fysik (1900-2015)



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