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Kinetic model of HIV infection including hematopoietic progenitor cells

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Mathematical Biosciences (0025-5564). Vol. 236 (2012), 1, p. 36-43.
[Artikel, refereegranskad vetenskaplig]

Recent experiments indicate that one of the likely reasons of the failure of eradication of HIV is in infection of hematopoietic progenitor cells. Such cells are nurtured in stem-cell niches residing in the bone marrow. Our generic four-variable kinetic model focused on this ingredient of HIV infection describes (i) a rapid increase of the population of infected CD4(+) T cells at the beginning of verimia, (ii) a sharp decline of this population due to immunological control, (iii) a long period of latency followed by a collapse of the immune system, and (iv) predicts that in the case of the therapy fully eradicating infected CD4(+) T cells the infection starts rapidly again after the therapy.

Nyckelord: HIV kinetics, Antiretroviral therapy, Hematopoietic progenitor cells, Lymphocytes, Immune-response cells, Mean-field kinetic equations, cellular-automata model, stem-cells, immune-response, t-cells, antiretroviral treatment, intracellular delay, viral replication, bone-marrow, virus, dynamics

Denna post skapades 2012-05-10.
CPL Pubid: 157493


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Institutionen för teknisk fysik, Kemisk fysik (1900-2015)


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