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Systems biology of yeast cell death

Ana Joyce Muñoz (Institutionen för kemi- och bioteknik, Systembiologi) ; Kwanjeera Wanichthanarak (Institutionen för kemi- och bioteknik, Systembiologi) ; Eugenio Meza (Institutionen för kemi- och bioteknik, Systembiologi) ; Dina Petranovic (Institutionen för kemi- och bioteknik, Systembiologi)
Fems Yeast Research (1567-1356). Vol. 12 (2012), 2, p. 249-265.
[Artikel, refereegranskad vetenskaplig]

Programmed cell death (PCD) (including apoptosis) is an essential process, and many human diseases of high prevalence such as neurodegenerative diseases and cancer are associated with deregulations in the cell death pathways. Yeast Saccharomyces cerevisiae, a unicellular eukaryotic organism, shares with multicellular organisms (including humans) key components and regulators of the PCD machinery. In this article, we review the current state of knowledge about cell death networks, including the modeling approaches and experimental strategies commonly used to study yeast cell death. We argue that the systems biology approach will bring valuable contributions to our understanding of regulations and mechanisms of the complex cell death pathways.

Nyckelord: yeast, programmed cell death, apoptosis systems biology, rat-liver mitochondria, bcl-2 protein family, saccharomyces-cerevisiae, fluorescent-probes, molecular-mechanisms, hydrogen-peroxide, dna, fragmentation, signaling networks, promotes apoptosis, caspase, activation

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Denna post skapades 2012-04-20. Senast ändrad 2013-11-06.
CPL Pubid: 156940


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)


Bioinformatik och systembiologi
Industriell bioteknik

Chalmers infrastruktur