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Applications of the Nicholas Reaction in the Synthesis of Natural Products

Nina Kann (Institutionen för kemi- och bioteknik, Organisk kemi)
Current Organic Chemistry (1385-2728). Vol. 16 (2012), 3, p. 322-334.
[Artikel, refereegranskad vetenskaplig]

The Nicholas reaction involves the treatment of a cobalt carbonyl-stabilized propargylic cation with a variety of nucleophiles to form a new carbon-carbon or carbon-heteroatom bond. Several features of this reaction make it especially well suited for applications in natural product synthesis, in particular when cyclic and polycyclic target molecules are involved. This review summarizes the results in this area from the last ten years, including approaches towards terpenes, alkaloids and marine natural products.

Nyckelord: Alkaloid, cobalt alkyne complex, marine polyether, natural product, synthesis, Nicholas reaction, terpene, acetylene cobalt complex, 8-membered cyclic ethers, jklm-ring fragment, stereoselective-synthesis, propargylic substitution, convergent, synthesis, organic-synthesis, formal synthesis, ciguatoxin 1b, enantioselective syntheses

Denna post skapades 2012-04-03.
CPL Pubid: 156408


Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Organisk kemi (2006-2014)


Organisk kemi

Chalmers infrastruktur