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High-Resolution Micropatterned Teflon AF Substrates for Biocompatible Nanofluidic Devices

Ilja Czolkos (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Bodil Hakonen (Institutionen för kemi- och bioteknik, Kärnkemi) ; Owe Orwar (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Aldo Jesorka (Institutionen för kemi- och bioteknik, Fysikalisk kemi)
Langmuir (0743-7463). Vol. 28 (2012), 6, p. 3200-3205.
[Artikel, refereegranskad vetenskaplig]

We describe a general photolithography-based process for the microfabrication of surface-supported Teflon AF structures. Teflon AF patterns primarily benefit from superior optical properties such as very low autofluorescence and a low refractive index. The process ensures that the Teflon AF patterns remain strongly hydrophobic in order to allow rapid lipid monolayer spreading and generates a characteristic edge morphology which assists directed cell growth along the structured surfaces. We provide application examples, demonstrating the well-controlled mixing of lipid films on Teflon AF structures and showing how the patterned surfaces can be used as biocompatible growth-directing substrates for cell culture. Chinese hamster ovary (CHO) cells develop in a guided fashion along the sides of the microstructures, selectively avoiding to grow over the patterned areas.

Nyckelord: lipid-bilayers, membranes, surfaces, films, adhesion, planar, growth, cells, area

Denna post skapades 2012-03-08.
CPL Pubid: 155719


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)
Institutionen för kemi- och bioteknik, Kärnkemi (2005-2014)



Chalmers infrastruktur