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Kinetic Studies to Investigate Lipoprotein Metabolism.

Jan Borén ; Marja-Riitta Taskinen ; Martin Adiels (Institutionen för matematiska vetenskaper ; Institutionen för medicin, avdelningen för molekylär och klinisk medicin ; Wallenberglaboratoriet)
Journal of internal medicine (1365-2796). Vol. 271 (2011), 2, p. 166-173.
[Artikel, forskningsöversikt]

To develop novel strategies for prevention and treatment of dyslipidaemia, it is essential to understand the pathophysiology of dyslipoproteinaemia in humans. Lipoprotein metabolism is a complex system in which abnormal concentrations of various lipoprotein particles can result from alterations in their rates of production, conversion and/or catabolism. Traditional methods that measure plasma lipoprotein concentrations only provide static estimates of lipoprotein metabolism and hence limited mechanistic information. By contrast, the use of tracers labelled with stable isotopes and mathematical modelling provides a powerful tool for probing lipid and lipoprotein kinetics in vivo and furthering understanding of the pathogenesis of dyslipoproteinaemia.

Nyckelord: Kinetics, apolipoprotein, mathematical modelling, VLDL

Denna post skapades 2012-01-11. Senast ändrad 2016-08-19.
CPL Pubid: 152269


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Institutioner (Chalmers)

Institutionen för medicin, avdelningen för molekylär och klinisk medicin (GU)
Wallenberglaboratoriet (GU)
Institutionen för matematiska vetenskaperInstitutionen för matematiska vetenskaper (GU)


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