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High serum total cholesterol is a long-term cause of osteoporotic fracture.

Penelope Trimpou ; Anders Odén (Institutionen för matematiska vetenskaper, matematisk statistik) ; Tomas Simonsson ; Lars Wilhelmsen ; Kerstin Landin-Wilhelmsen
Osteoporosis international (0937-941X). Vol. 22 (2011), 5, p. 1615-20.
[Artikel, refereegranskad vetenskaplig]

Risk factors for osteoporotic fractures were evaluated in 1,396 men and women for a period of 20 years. Serum total cholesterol was found to be an independent osteoporotic fracture risk factor whose predictive power improves with time. The purpose of this study was to evaluate long-term risk factors for osteoporotic fracture. A population random sample of men and women aged 25-64 years (the Gothenburg WHO MONICA project, N = 1,396, 53% women) was studied prospectively. The 1985 baseline examination recorded physical activity at work and during leisure time, psychological stress, smoking habits, coffee consumption, BMI, waist/hip ratio, blood pressure, total, HDL and LDL cholesterol, triglycerides, and fibrinogen. Osteoporotic fractures over a period of 20 years were retrieved from the Gothenburg hospital registers. Poisson regression was used to analyze the predictive power for osteoporotic fracture of each risk factor. A total number of 258 osteoporotic fractures occurred in 143 participants (10.2%). As expected, we found that previous fracture, smoking, coffee consumption, and lower BMI each increase the risk for osteoporotic fracture independently of age and sex. More unexpectedly, we found that the gradient of risk of serum total cholesterol to predict osteoporotic fracture significantly increases over time (p = 0.0377). Serum total cholesterol is an independent osteoporotic fracture risk factor whose predictive power improves with time. High serum total cholesterol is a long-term cause of osteoporotic fracture.

Nyckelord: Adult, Anthropometry, methods, Cholesterol, blood, Coffee, adverse effects, Epidemiologic Methods, Female, Humans, Life Style, Male, Middle Aged, Motor Activity, Osteoporotic Fractures, blood, epidemiology, etiology, Recurrence, Smoking, adverse effects, epidemiology, Sweden, epidemiology



Denna post skapades 2012-01-02. Senast ändrad 2016-07-18.
CPL Pubid: 151362

 

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Institutioner (Chalmers)

Institutionen för medicin, avdelningen för invärtesmedicin (2006-2011)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi (GU)
Institutionen för medicin, avdelningen för akut och kardiovaskulär medicin (2006-2011)

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Dermatologi och venereologi

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