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Calculation of nanoparticle capture efficiency in magnetic drug targeting

Adil Mardinoglu (Institutionen för kemi- och bioteknik, Systembiologi)
Journal of Magnetism and Magnetic Materials Vol. 320 (2008), 23, p. 3272-3275.
[Artikel, refereegranskad vetenskaplig]

The implant assisted magnetic targeted drug delivery system of Avilés, Ebner and Ritter, which uses high gradient magnetic separation (HGMS) is considered. In this 2D model large ferromagnetic particles are implanted as seeds to aid collection of multiple domain nanoparticles (radius ). Here, in contrast, single domain magnetic nanoparticles (radius in 20–100 nm) are considered and the Langevin function is used to describe the magnetization. Simulations based on this model were performed using the open source C++ finite volume library OpenFOAM. The simulations indicate that use of the Langevin function predicts greater collection efficiency than might be otherwise expected.

Nyckelord: Magnetic drug targeting; High gradient magnetic separation (HGMS); Magnetic nanoparticle; Simulation; Magnetic seed



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Denna post skapades 2011-12-16.
CPL Pubid: 150282

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)

Ämnesområden

Livsvetenskaper
Bioinformatik och systembiologi
Folkhälsomedicinska forskningsområden

Chalmers infrastruktur