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Industrial glucoamylase fed-batch benefits from oxygen limitation and high osmolarity

L. Pedersen ; K. Hansen ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi) ; A. E. Lantz ; J. Thykaer
Biotechnology and Bioengineering (0006-3592). Vol. 109 (2012), 1, p. 116-124.
[Artikel, refereegranskad vetenskaplig]

The market for glucoamylase is large and very competitive and the production process has been optimized through several decades. So far a thorough characterization of the process has not been published, but previous academic reports suggest that the process suffers from severe byproduct formation. In this study we have carried out a thorough characterization of a process as close as possible to the industrial reality. The results show that the oxygen-limited phases of the process have the highest glucoamylase yields on carbon and that the byproducts are efficiently reused in late phases of the process. An alternative process with low glucose concentration show that high osmolarity is beneficial for the process, and we conclude that oxygen limitation, high osmolarity, and the associated byproduct metabolism are important for the efficiency of the process.

Nyckelord: Aspergillus niger, glucoamylase, oxygen limitation, enzyme production, fermentation

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Denna post skapades 2011-12-16. Senast ändrad 2014-10-27.
CPL Pubid: 150215


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)


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Industriell bioteknik

Chalmers infrastruktur