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Dietary herring improves plasma lipid profiles and reduces atherosclerosis in obese low-density lipoprotein receptor-deficient mice

Britt G. Gabrielsson (Institutionen för kemi- och bioteknik, Livsmedelsvetenskap) ; Johannes Wikström ; Robert Jakubowicz ; Sofia Marmon (Institutionen för kemi- och bioteknik, Livsmedelsvetenskap) ; Nils-Gunnar Carlsson (Institutionen för kemi- och bioteknik, Livsmedelsvetenskap) ; Nina Jansson ; Li-Ming Gan ; Ingrid Undeland (Institutionen för kemi- och bioteknik, Livsmedelsvetenskap) ; Malin Lönn ; Agneta Holmäng ; Ann-Sofie Sandberg (Institutionen för kemi- och bioteknik, Livsmedelsvetenskap)
International Journal of Molecular Medicine (1107-3756). Vol. 29 (2012), 3, p. 331-37.
[Artikel, refereegranskad vetenskaplig]

Diet is a significant modifiable risk factor for cardiovascular disease and high fish intake has been associated with vascular health in population studies. However, intervention studies have been inconclusive. In this study, male low-density lipoprotein receptor-deficient mice were given 16-week high fat/high sucrose diets, supplemented with either minced herring fillets or minced beef. The diets were matched in total fat and cholesterol content; taurine content and fatty acid composition was analysed. Body weights were recorded throughout the study; plasma lipids were analysed at week 8 and 16. Body composition and adipocyte size were evaluated at study end. Atherosclerosis was evaluated at week 12 (ultrasound) and at termination (en face histology). Herring-fed mice had a higher proportion of long-chain n-3 polyunsaturated fatty acids in the hepatic triacylglycerides (TAG) and phospholipid fractions. The herring-fed mice had increased body weight (P=0.007), and reduced epididymal adipocyte size (P=0.009), despite similar food intake and body composition as the beef-fed mice. The herring-fed mice had lower plasma TAG and very-low-density lipoprotein (VLDL)-cholesterol concentrations throughout the study (TAG; P=0.0012 and 0.004, VLDL-cholesterol; P=0.006 and 0.041, week 8 and 16, respectively). At week 16, the herring-fed had higher plasma concentrations of HDL-cholesterol (P=0.004) and less atherosclerotic lesions in the aortic arch (P=0.007) compared with the beef-fed mice. In conclusion, dietary herring in comparison to beef markedly improved vascular health in this mouse model, suggesting that herring provides an added value beyond its content of macronutrients.

Nyckelord: low-density lipoprotein receptor-deficient, en face histology, lipoprotein particle cholesterol profile, herring



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Denna post skapades 2011-12-13. Senast ändrad 2014-11-10.
CPL Pubid: 150043

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Livsmedelsvetenskap (2005-2014)
Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi (GU)
Institutionen för biomedicin, avdelningen för klinisk kemi och transfusionsmedicin (GU)

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Endokrinologi
Kardiovaskulär medicin
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