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Exploring the role of phosphorus substituents on the enantioselectivity of Ru-catalysed ketone hydrogenation using tridentate phosphine-diamine ligands

S. D. Phillips ; Kristian Hans Ola Andersson (Institutionen för kemi- och bioteknik, Organisk kemi) ; Nina Kann (Institutionen för kemi- och bioteknik, Organisk kemi) ; M. T. Kuntz ; M. B. France ; P. Wawrzyniak ; M. L. Clarke
Catalysis Science & Technology (2044-4753). Vol. 1 (2011), 8, p. 1336-1339.
[Artikel, refereegranskad vetenskaplig]

Methods to produce a range of new phosphine-diamine ligands from phosphino-aldehydes have been developed and a hypothesis that larger P-substituents would increase the enantioselectivity towards the (S) isomer in Ru-catalysed ketone hydrogenation of acetophenone has been examined; the successful validation of this hypothesis is further evidence that the mechanism of these catalysts involves a secondary amine assisted reduction.

Nyckelord: ruthenium hydride complexes, asymmetric hydrogenation, aromatic ketones, aminophosphine ligands, hybrid ligands, imines, alkylation, proline, rhodium, design



Denna post skapades 2011-11-16.
CPL Pubid: 148599

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Organisk kemi (2006-2014)

Ämnesområden

Kemi

Chalmers infrastruktur