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Nucleic acid–metal interactions: V. The effect of silver(I) on the structures of A- and B-DNA forms

Bengt Nordén (Institutionen för fysikalisk kemi) ; Yukio Matsuoka (Institutionen för fysikalisk kemi) ; T. Kurucsev
Biopolymers (0006-3525). Vol. 25 (1986), 8, p. 1531-1545.
[Artikel, refereegranskad vetenskaplig]

The interaction of silver(I) with DNA has been studied with uv LD in aqueous solution and in a humid anisotropic poly(vinyl alcohol) host (B-DNA) and also in 80% ethanolic solution (A-DNA). Addition of silver ions has a pronounced effect on the dichroic spectra of DNA, indicating that the DNA structure is significantly altered. By correlation with calculated reduced LD spectra, using intensities and moments of the corresponding electronic transitions of the DNA bases, the experimental spectra of DNA at high silver content may be interpreted in terms of tilt and roll angles of the bases in the double helix. In ethanolic A-DNA solution there is a pronounced decrease in the orientation by flow of DNA, suggesting that the complexation of DNA to silver may be accompanied by the formation of compact tertiary structures.



Denna post skapades 2011-11-14.
CPL Pubid: 148449

 

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Institutioner (Chalmers)

Institutionen för fysikalisk kemi (1900-2003)

Ämnesområden

Biokemi
Cell- och molekylärbiologi

Chalmers infrastruktur