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The effect of hydroxyapatite nanocrystals on early bone formation surrounding dental implants.

Lory Melin Svanborg ; Maria Hoffman ; Martin Andersson (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; F Currie ; P Kjellin ; Ann Wennerberg
International journal of oral and maxillofacial surgery (1399-0020). Vol. 40 (2011), 3, p. 308-15.
[Artikel, refereegranskad vetenskaplig]

The knowledge of how nanostructures might affect early bone healing and osseointegration is limited. The aim of this study was to investigate if nanometer thick coatings of hydroxyapatite nanocrystals applied on a moderately rough surface might enhance early bone healing on screw-shaped dental implants and to evaluate if the thickness of the coat influences healing. Sandblasted and acid etched titanium implants coated with two different thicknesses of hydroxyapatite (test implants) and sandblasted and acid etched titanium implants (control implants), were inserted in rabbit tibia. After a healing time of 2, 4 and 9 weeks, a removal torque analysis and a histological evaluation were performed. The results from the removal torque analysis showed a tendency for higher values for the double coated hydroxyapatite after 4 weeks and for both the coated surfaces after 9 weeks of healing. The histological evaluations indicated slightly more new bone formation with the coated implants compared with the control; the differences did not reach statistical significance. The present study could not support the importance of nanometer thick coatings of hydroxyapatite nanocrystals in early bone healing, at least not when applied on a blasted and etched surface and placed in a cortical bone.

Nyckelord: Acid Etching, Dental, Animals, Coated Materials, Biocompatible, chemistry, Dental Etching, Dental Implants, Dental Materials, chemistry, Dental Prosthesis Design, Durapatite, chemistry, Materials Testing, Microscopy, Electron, Scanning, Models, Animal, Nanoparticles, chemistry, Osseointegration, physiology, Osteogenesis, physiology, Photoelectron Spectroscopy, Rabbits, Surface Properties, Tibia, pathology, surgery, Time Factors, Titanium, chemistry, Torque, nanostructures, surface topography, hydroxyapatite coat, dental, implants, in vivo study, acid-etched surface, titanium implants, calcium-phosphate, in-vitro, osteoblast adhesion, enhanced functions, removal torque, oral implants, coatings, vivo



Denna post skapades 2011-09-15. Senast ändrad 2012-08-20.
CPL Pubid: 146235

 

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Institutioner (Chalmers)

Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för biomaterialvetenskap (GU)
Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)

Ämnesområden

Kirurgi
Odontologi
Biomaterial
Kirurgisk forskning

Chalmers infrastruktur