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THE CD OF LIGAND-DNA SYSTEMS .1. POLY(DG-DC) B-DNA

Reidar Lyng (Institutionen för fysikalisk kemi) ; A. Rodger ; Bengt Nordén (Institutionen för fysikalisk kemi)
Biopolymers (0006-3525). Vol. 31 (1991), 14, p. 1709-1720.
[Artikel, refereegranskad vetenskaplig]

A systematic theoretical study of the CD of double-stranded poly (dG-dC) and its complexes with small molecules is presented. The intrinsic CD of the polymer and the induced CD of a transition belonging to a molecule bound to DNA are calculated using the matrix method. The calculations show considerable differences between pyrimidine-purine and purine-pyrimidine binding sites, and we find that the induced CD of a groove bound molecule is one order of magnitude stronger than that of an intercalated molecule. The results form a sound basis for interpreting the CD of ligand-DNA systems in terms of molecular geometry, interactions, and spectroscopy.

Nyckelord: dipole allowed transitions, induced circular-dichroism, nucleic-acids, drug-binding, dapi, polynucleotides, perturbation, fluorescence, complexes, model



Denna post skapades 2011-09-07.
CPL Pubid: 145892

 

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Institutioner (Chalmers)

Institutionen för fysikalisk kemi (1900-2003)

Ämnesområden

Biokemi
Molekylärbiologi

Chalmers infrastruktur