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Early interactions between leukocytes and three different potentially bioactive titanium surface modifications

Anna Arvidsson ; Per Malmberg ; Per Kjellin ; Fredrik Currie ; Martin Arvidsson (Institutionen för teknikens ekonomi och organisation, Industriell kvalitetsutveckling) ; Victoria Franke Stenport
Journal of Biomedical Materials Research. Part B - Applied biomaterials (1552-4973). Vol. 97 (2011), 2, p. 364-72.
[Artikel, refereegranskad vetenskaplig]

The aim of the present study was to compare the early interactions between leukocytes and three different surface modifications, suggested as bioactive. Blasted titanium discs were modified by alkali and heat treatment, sodium fluoride treatment, or hydroxyapatite coating. A number of these discs were also immersed in simulated body fluid (SBF) for a week, a treatment which yielded high levels of calcium and phosphate on each surface type. The specimens were exposed for human venous blood for 32 minutes and the respiratory burst response was measured in terms of reactive oxygen species with a luminometer, and coverage of viable cells with a fluorescence microscope after staining steps. The topography, morphology, and chemistry of the surfaces were evaluated with optical interferometry and scanning electron microscopy/energy dispersive X-ray analysis (SEM/EDX). A high respiratory burst response was found for HA coated titanium in comparison with the other surface groups (p < 0.0005). The SBF immersion resulted in an increased respiratory burst response (p < 0.0005) and removed statistically significant differences between the surface groups. Thus, the results in the present study indicate that different titanium surface modifications influence the early inflammatory response differently, and that calcium phosphate compounds increase the inflammatory response.

Nyckelord: Body Fluids, chemistry, Coated Materials, Biocompatible, chemistry, metabolism, Durapatite, chemistry, Hot Temperature, Humans, Leukocytes, immunology, Materials Testing, Reactive Oxygen Species, metabolism, Respiratory Burst, physiology, Sodium Fluoride, chemistry, Surface Properties, Titanium, chemistry, metabolism

Denna post skapades 2011-08-25. Senast ändrad 2015-06-12.
CPL Pubid: 145037


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Institutioner (Chalmers)

Institutionen för kliniska vetenskaper, sektionen för anestesi, biomaterial och ortopedi, Avdelningen för biomaterialvetenskap (GU)
Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi (GU)
Institutionen för teknikens ekonomi och organisation, Industriell kvalitetsutveckling (2005-2016)



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