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The effect of live, attenuated measles vaccine and measles infection on measles antibody levels in serum and CSF of patients with multiple sclerosis or clinically isolated syndrome.

Cecilia Ahlgren ; Anders Odén (Institutionen för matematiska vetenskaper, matematisk statistik) ; Sara Haghighi ; Oluf Andersen ; Tomas Bergström ; Jan Lycke
Journal of neuroimmunology (1872-8421). Vol. 235 (2011), 1-2, p. 98-103.
[Artikel, refereegranskad vetenskaplig]

High occurrence of measles, rubella and varicella zoster antibodies has been used as a biomarker for MS (the MRZ test). We analyzed measles antibody titres with respect to measles infection/measles vaccination status in 166 patients with MS or clinically isolated syndrome. Fifty blood donors served as controls. Measles vaccination yielded CSF measles antibodies in fewer patients (62%) than measles infection did (87%, p=0.001) and yielded lower measles titres in both serum and CSF (p<0.001). Controls had lower CSF measles titres than patients with measles vaccination alone (p<0.001). Childhood vaccinations probably reduce the sensitivity of the MRZ diagnostic test for MS.

Nyckelord: Adolescent, Adult, Antibodies, Viral, blood, cerebrospinal fluid, Child, Preschool, Demyelinating Diseases, blood, cerebrospinal fluid, immunology, Female, Humans, Male, Measles, blood, cerebrospinal fluid, immunology, Measles Vaccine, immunology, therapeutic use, Middle Aged, Multiple Sclerosis, blood, cerebrospinal fluid, immunology, Vaccines, Attenuated, immunology, therapeutic use, Young Adult



Denna post skapades 2011-08-22. Senast ändrad 2012-07-20.
CPL Pubid: 144674

 

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Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering (2006-2016)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för biomedicin, avdelningen för infektionssjukdomar (GU)

Ämnesområden

MEDICIN OCH HÄLSOVETENSKAP

Chalmers infrastruktur