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EXPERIMENTAL SEARCH FOR COMBINED AC AND DC MAGNETIC-FIELD EFFECTS ON ION CHANNELS

Sheila Galt (Institutionen för mikrovågsteknik) ; J. Sandblom ; Yngve Hamnerius (Institutionen för mikrovågsteknik) ; P. Hojevik ; Elisabeth Saalman ; Bengt Nordén (Institutionen för fysikalisk kemi)
Bioelectromagnetics (0197-8462). Vol. 14 (1993), 4, p. 315-327.
[Artikel, refereegranskad vetenskaplig]

The hypothesis that specific combinations of DC and low frequency AC magnetic fields at so-called cyclotron-resonance conditions could affect the transport of ions through ion channels, or alter the kinetics of ion channels (opening and closing rates), has been tested. As a model system, the ion channels formed by gramicidin A incorporated in lipid bilayer membranes were studied. No significant changes in channel conductance, average lifetime, or formation rate as a function of applied fields could be detected over a wide range of frequencies and field strengths. Experiments were carried out to measure the time-resolved single-channel events and the average conductances of many-channel events in the presence of K+ and H+ ions. The channel blocking effect of Ca++ was also studied. (C) 1993 Wiley-Liss, Inc.

Nyckelord: elf, cyclotron resonance, gramicidin, bilayer membrane, potassium ion, brain-tissue invitro, cyclotron-resonance, gramicidin-a, electric-fields, low-frequency, radiation, behavior, binding, efflux



Denna post skapades 2011-08-17.
CPL Pubid: 144414

 

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Institutioner (Chalmers)

Institutionen för mikrovågsteknik (1900-2003)
Institutionen för fysikalisk kemi (1900-2003)

Ämnesområden

Biofysikalisk kemi
Biologiska vetenskaper

Chalmers infrastruktur