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Effect of microwave radiation on permeability of liposomes. Evidence against non-thermal leakage

Björn Bergqvist (Institutionen för mikrovågsteknik) ; Lars Arvidsson (Institutionen för biokemi och biofysik) ; Eva Pettersson (Institutionen för biokemi och biofysik) ; Sheila Galt (Institutionen för mikrovågsteknik) ; Elisabeth Saalman ; Yngve Hamnerius (Institutionen för mikrovågsteknik) ; Bengt Nordén (Institutionen för fysikalisk kemi)
Biochimica Et Biophysica Acta-General Subjects (0304-4165). Vol. 1201 (1994), 1, p. 51-54.
[Artikel, refereegranskad vetenskaplig]

The effect of 2.45 GHz microwave radiation on the permeability of unilamellar phosphatidylcholine liposomes has been studied. Leakage of 5(6)-calboxyfluorescein from the liposomes was measured using spectrofluorimetry after exposure to either microwaves or thermal heating for 5-20 min intervals. The exposure temperature, 37.6 +/- 0.5 degrees C, was well above the phase transition temperature of the lipid membrane. The microwave exposure did not result in any non-thermal increase in permeability above that produced by thermal heating. This study refutes the results reported by Saalman et al. [1] in which an increased liposome permeability due to microwave exposure was reported. The refined analysis in the present study shows that this increased liposome permeability was not a non-thermal microwave effect.

Nyckelord: membrane permeability, liposome, nonthermal effect, microwave radiation, fluorescence, 5(6)-carboxyfluorescein, phase-transition, erythrocytes, temperature, efflux

Denna post skapades 2011-08-10.
CPL Pubid: 144022


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Institutioner (Chalmers)

Institutionen för mikrovågsteknik (1900-2003)
Institutionen för biokemi och biofysik (1977-1999)
Institutionen för fysikalisk kemi (1900-2003)



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