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Prospects for systems biology and modeling of the gut microbiome

Fredrik H. Karlsson (Institutionen för kemi- och bioteknik, Systembiologi) ; Intawat Nookaew (Institutionen för kemi- och bioteknik, Systembiologi) ; Dina Petranovic (Institutionen för kemi- och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi)
Trends in Biotechnology (0167-7799). Vol. 29 (2011), 6, p. 251-258.
[Artikel, refereegranskad vetenskaplig]

Abundant microorganisms that inhabit the human intestine are implicated in health and disease. The gut microbiome has been studied with metagenomic tools, and over 3 million genes have been discovered, constituting a 'parts list' of this ecosystem; further understanding requires studies of the interacting parts. Mouse models have provided a glimpse into the microbiota and host interactions at metabolic and immunologic levels; however, to provide more insight, there is a need to generate mathematical models that can reveal genotype-phenotype relationships and provide scaffolds for integrated analyses. To this end, we propose the use of genome-scale metabolic models that have successfully been used in studying interactions between human hosts and microbes, as well as microbes in isolation and in communities.

Nyckelord: chain fatty-acids, inflammatory bowel diseases, protein-coupled, receptor, human colonic microbiota, diet-induced obesity, metabolic, reconstruction, bacterial mutualism, high-throughput, networks, butyrate



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Denna post skapades 2011-06-29. Senast ändrad 2014-10-27.
CPL Pubid: 142665

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)

Ämnesområden

Livsvetenskaper
Industriell bioteknik

Chalmers infrastruktur

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Systems Biology of the Gut Microbiome in Metabolic Diseases