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Interleukin 28B Gene Variation at rs12979860 Determines Early Viral Kinetics During Treatment in Patients Carrying Genotypes 2 or 3 of Hepatitis C Virus

Magnus Lindh ; Martin Lagging ; M. Färkkilä ; N. Langeland ; K. Mörch ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Gunnar Norkrans ; C. Pedersen ; M. R. Buhl ; Johan Westin ; Kristoffer Hellstrand
Journal of Infectious Diseases (1537-6613). Vol. 203 (2011), 12, p. 1748-1752.
[Artikel, refereegranskad vetenskaplig]

Single-nucleotide polymorphisms upstream of the interleukin 28B (interferon lambda 3) gene (IL28B) strongly influence treatment efficacy in patients carrying hepatitis C virus (HCV) of genotype 1. In patients receiving 12 or 24 weeks of interferon-ribavirin therapy for infection with genotype 2 or 3 (n = 341), we found that rs12979860 strikingly determined the first phase of viral elimination (P < .001). In patients treated for 24 weeks, rs12979860 also predicted the rate of sustained virologic response (P = .02), especially among those with high baseline HCV RNA levels (P = .002) or older than 45 years (P = .01). Patients carrying CCrs12979860 had higher baseline HCV RNA levels (P < .001) and did not, when treated for 12 weeks, achieve sustained virologic response more often than those carrying CTrs1297986 or TTrs1297986. The results indicate that IL28B gene testing may identify patients carrying genotype 2 or 3 who could benefit from extended treatment.

Nyckelord: il28b, ribavirin



Denna post skapades 2011-06-13. Senast ändrad 2015-01-16.
CPL Pubid: 141556

 

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Institutioner (Chalmers)

Institutionen för biomedicin, avdelningen för infektionssjukdomar (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)

Ämnesområden

Dermatologi och venereologi

Chalmers infrastruktur