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Magnetically Triggered Release From Giant Unilamellar Vesicles: Visualization By Means Of Confocal Microscopy

S. Nappini ; T. Al Kayal ; D. Berti ; Bengt Nordén (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; P. Baglioni
Journal of Physical Chemistry Letters (1948-7185). Vol. 2 (2011), 7, p. 713-718.
[Artikel, refereegranskad vetenskaplig]

Magnetically triggered release from magnetic giant unilamellar vesicles (GUVs) loaded with Alexa fluorescent dye was studied by means of confocal laser scanning microscopy (CLSM) under a low-frequency alternating magnetic field (LF-AMP). Core/shell cobalt ferrite nanoparticles coated with rhodamine B isothiocyanate (MP@SiO2(RITC)) were prepared and adsorbed on the GUV membrane. The MP@SiO2-(RITC) location and distribution on giant lipid vesicles were determined by 3D-CLSM projections, and their effect on the release properties and GUV permeability under a LF-AMF was investigated by CLSM time-resolved experiments. We show that the mechanism of release of the fluorescent dye during the LF-AMF exposure is induced by magnetic nanoparticle energy and mechanical vibration, which promote the perturbation of the GUV membrane without its collapse.

Nyckelord: cobalt-ferrite nanoparticles, iron-oxide nanoparticles, controlled, drug-release, fluid-loaded liposomes, delivery systems, quantum dots, magnetoliposomes, surfactant, field, stabilization

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Denna post skapades 2011-05-13.
CPL Pubid: 140649


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)


Nanovetenskap och nanoteknik

Chalmers infrastruktur