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Robust servo control of a novel type 1 diabetic model

L. Kovacs ; Balazs Kulcsar (Institutionen för signaler och system, Reglerteknik) ; A. Gyorgy ; Z. Benyo
Optimal Control Applications & Methods (0143-2087). Vol. 32 (2011), 2, p. 215-238.
[Artikel, refereegranskad vetenskaplig]

Robust servo control of a model-based biomedical application is presented in the article. The glucose-insulin control of type 1 diabetic patients is considered to be solved using the results of post-modern robust control principles. The paper uses a recently published glucose-insulin model and presents the transformation of the model to describe the dynamics of type 1 diabetes mellitus. The nonlinear plant is then linearized at a given steady state point. In order to characterize the uncertainty around the nominal model in frequency domain, a parametric nonlinear model sensitivity analysis is performed using gridding method. The aim of the paper is to underline the viability of the robust servo, linear mu-control algorithm tested in highly nonlinear closed-loop simulation environment. Using two degree-of-freedom robust controller, the structured singular value of the closed-loop is designed to fulfill the robust performance requirements and assure glucose level control. Glucose level tracking is ensured under simulated and realistic exogenous meal disturbances.

Nyckelord: type 1 diabetes, robust control, mu-synthesis, glucose tracking, uncertainty, blood-glucose control, insulin sensitivity, intravenous glucose, control design, mellitus, systems, tolerance, algorithm, delivery, invivo

Denna post skapades 2011-04-28. Senast ändrad 2012-05-04.
CPL Pubid: 139915


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