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Are the complex distributed genetic networks inherently oscillatory and chaotic?

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Jetp Letters (0021-3640). Vol. 93 (2011), 1, p. 41-45.
[Artikel, refereegranskad vetenskaplig]

Complex mRNA-protein networks with distributed regulation of gene transcription are often mimicked by random Boolean networks. According to this mapping, the gene-expression kinetics are expected to depend strongly on the network connectivity, m. Specifically, the kinetics are predicted to be oscillatory or chaotic for m > 2. We analyze this problem in more detail by using an accurate model explicitly describing the mRNA-protein interplay with randomly organized transcriptional regulation. Contrary to the expectations, our mean-field calculations and Monte Carlo simulations performed for m = 1, 2 and 4 show that oscillations and chaos are lacking irrespective of m.

Nyckelord: expression, models

Denna post skapades 2011-04-21.
CPL Pubid: 139651


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Institutionen för teknisk fysik, Kemisk fysik (1900-2015)



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