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Hierarchical genetic networks and noncoding RNAs

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Chaos (1054-1500). Vol. 20 (2010), 4,
[Artikel, refereegranskad vetenskaplig]

In eukaryotic cells, many genes are transcribed into noncoding RNAs. Such RNAs may associate with mRNAs and inhibit their translation and facilitate degradation. To clarify what may happen in this case, we propose a kinetic model describing the effect of noncoding RNAs on a mRNA-protein network with the hierarchical three-layer architecture. For positive regulation of the layers, our model predicts either bistability with a fairly narrow hysteresis loop or a unique steady state. For negative or mixed regulation, the steady state is found to be unique.

Nyckelord: transcriptional regulatory network, distinct messenger-rnas, nonprotein, coding rna, escherichia-coli, microrna regulation, decay-rates, expression, oscillations, bistability, protein

Denna post skapades 2011-03-04. Senast ändrad 2012-02-17.
CPL Pubid: 137602


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Institutionen för teknisk fysik, Kemisk fysik (1900-2015)


Tillämpad matematik

Chalmers infrastruktur