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Prospects of yeast systems biology for human health: integrating lipid, protein and energy metabolism

Dina Petranovic (Institutionen för kemi- och bioteknik, Systembiologi) ; Keith Tyo (Institutionen för kemi- och bioteknik, Systembiologi) ; Goutham N. Vemuri (Institutionen för kemi- och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi)
Fems Yeast Research (1567-1356). Vol. 10 (2010), 8, p. 1046-1059.
[Artikel, refereegranskad vetenskaplig]

The yeast Saccharomyces cerevisiae is a widely used model organism for studying cell biology, metabolism, cell cycle and signal transduction. Many regulatory pathways are conserved between this yeast and humans, and it is therefore possible to study pathways that are involved in disease development in a model organism that is easy to manipulate and that allows for detailed molecular studies. Here, we briefly review pathways involved in lipid metabolism and its regulation, the regulatory network of general metabolic regulator Snf1 (and its human homologue AMPK) and the proteostasis network with its link to stress and cell death. All the mentioned pathways can be used as model systems for the study of homologous pathways in human cells and a failure in these pathways is directly linked to several human diseases such as the metabolic syndrome and neurodegeneration. We demonstrate how different yeast pathways are conserved in humans, and we discuss the possibilities of using the systems biology approach to study and compare the pathways of relevance with the objective to generate hypotheses and gain new insights.

Nyckelord: yeast systems biology, energy metabolism, proteostasis, endoplasmic-reticulum stress, programmed cell-death, saccharomyces-cerevisiae, transcription factors, oxidized proteins, upstream kinase, global analysis, snf1 kinase, rat-liver, carboxylase, activity

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Denna post skapades 2011-02-14. Senast ändrad 2016-07-12.
CPL Pubid: 136819


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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)


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Chalmers infrastruktur