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HIV-1 viral escape in cerebrospinal fluid of subjects on suppressive antiretroviral treatment.

Arvid Edén ; Dietmar Fuchs ; Lars Hagberg ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Serena Spudich ; Bo Svennerholm ; Richard W Price ; Magnus Gisslén
The Journal of infectious diseases (1537-6613). Vol. 202 (2010), 12, p. 1819-25.
[Artikel, refereegranskad vetenskaplig]

Occasional cases of viral escape in cerebrospinal fluid (CSF) despite suppression of plasma human immunodeficiency virus type 1 (HIV-1) RNA have been reported. We investigated CSF viral escape in subjects treated with commonly used antiretroviral therapy regimens in relation to intrathecal immune activation and central nervous system penetration effectiveness (CPE) rank.

Nyckelord: Anti-HIV Agents, Blood-Brain Barrier, Cerebrospinal Fluid, virology, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, HIV Infections, drug therapy, virology, HIV-1, isolation & purification, Humans, Male, Middle Aged, Neopterin, analysis, Plasma, virology, RNA, Viral, isolation & purification, Reverse Transcriptase Polymerase Chain Reaction, Treatment Outcome, Viral Load



Denna post skapades 2011-01-19. Senast ändrad 2015-01-16.
CPL Pubid: 135145

 

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Institutioner (Chalmers)

Institutionen för biomedicin, avdelningen för infektionssjukdomar (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)

Ämnesområden

Infektionsmedicin

Chalmers infrastruktur