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Studies of glycolytic flux regulation/control using permeabilised yeast cells

Eva Albers (Institutionen för kemi- och bioteknik, Industriell Bioteknik )
Proceedings of 14th Workshop of International Study Group for Systems Biology (ISGSB) p. 97-102. (2010)
[Konferensbidrag, övrigt]

In this work the correlation between levels of adenosine nucleotides and glycolytic flux was studied using a permeabilised cell system by experiments and in silico simulations using a kinetic model of glycolysis. Experimentally, using a flow-through chamber, the ATP level was correlated to glycolytic flux by a parabolic relation with a maximum at 2-3 mM of ATP. The kinetic model did not describe this parabolic correlation; at high ATP levels above 4 mM the flux was further increased. Thus, other mechanisms than described by the kinetic equations used in the model are important at high ATP levels to reduce the glycolytic flux.



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Denna post skapades 2011-01-05. Senast ändrad 2016-01-12.
CPL Pubid: 132502

 

Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Industriell Bioteknik (2008-2014)

Ämnesområden

Livsvetenskaper
Biokemi
Mikrobiologi

Chalmers infrastruktur