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Sustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide

J. Ge ; G. B. Jacobson ; T. Lobovkina ; Krister Holmberg (Institutionen för kemi- och bioteknik, Teknisk ytkemi) ; R. N. Zare
Chemical Communications (1359-7345). Vol. 46 (2010), 47, p. 9034-9036.
[Artikel, refereegranskad vetenskaplig]

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO2. The microemulsion consists of a transfer RNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl beta-D-glucopyranoside, and the cosurfactant n-butanol.

Nyckelord: in-vivo, delivery, rna, sirna, microspheres, interference, emulsions, mechanism



Denna post skapades 2010-12-20. Senast ändrad 2012-02-17.
CPL Pubid: 131388

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Teknisk ytkemi (2005-2014)

Ämnesområden

Kemi

Chalmers infrastruktur