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**Harvard**

Rodhe, P., Drobin, D., Hahn, R., Wennberg, B., Lindahl, C., Sjöstrand, F. och Svensen, C. (2010) *Modelling of peripheral fluid accumulation after a crystalloid bolus in female volunteers - a mathematical study*.

** BibTeX **

@article{

Rodhe2010,

author={Rodhe, P. and Drobin, D. and Hahn, R.G. and Wennberg, Bernt and Lindahl, C. and Sjöstrand, F. and Svensen, C.H.},

title={Modelling of peripheral fluid accumulation after a crystalloid bolus in female volunteers - a mathematical study},

journal={Computational and Mathematical Methods in Medicine},

issn={1748-670X},

volume={11},

issue={4},

pages={341-351},

abstract={Objective. To simultaneously model plasma dilution and urinary output in female volunteers. Methods. Ten healthy female non-pregnant volunteers, aged 21-39 years (mean 29), with a bodyweight of 58-67kg (mean 62.5kg) participated. No oral fluid or food was allowed between midnight and completion of the experiment. The protocol included an infusion of acetated Ringer's solution, 25ml/kg over 30min. Blood samples (4ml) were taken every 5min during the first 120min, and thereafter the sampling rate was every 10min until the end of the experiment at 240min. A standard bladder catheter connected to a drip counter to monitor urine excretion continuously was used. The data were analysed by empirical calculations as well as by a mathematical model. Results. Maximum urinary output rate was found to be 19 (13-31) ml/min. The subjects were likely to accumulate three times as much of the infused fluid peripherally as centrally; 1/=2.7 (2.0-5.7). Elimination efficacy, Eeff, was 24 (5-35), and the basal elimination kb was 1.11 (0.28-2.90). The total time delay Ttot of urinary output was estimated as 17 (11-31) min. Conclusion. The experimental results showed a large variability in spite of a homogenous volunteer group. It was possible to compute the infusion amount, plasma dilution and simultaneous urinary output for each consecutive time point and thereby the empirical peripheral fluid accumulation. The variability between individuals may be explained by differences in tissue and hormonal responses to fluid boluses, which needs to be further explored.},

year={2010},

keywords={anaesthesia, fluids, kinetics, modelling, peripheral space},

}

** RefWorks **

RT Journal Article

SR Electronic

ID 130100

A1 Rodhe, P.

A1 Drobin, D.

A1 Hahn, R.G.

A1 Wennberg, Bernt

A1 Lindahl, C.

A1 Sjöstrand, F.

A1 Svensen, C.H.

T1 Modelling of peripheral fluid accumulation after a crystalloid bolus in female volunteers - a mathematical study

YR 2010

JF Computational and Mathematical Methods in Medicine

SN 1748-670X

VO 11

IS 4

SP 341

OP 351

AB Objective. To simultaneously model plasma dilution and urinary output in female volunteers. Methods. Ten healthy female non-pregnant volunteers, aged 21-39 years (mean 29), with a bodyweight of 58-67kg (mean 62.5kg) participated. No oral fluid or food was allowed between midnight and completion of the experiment. The protocol included an infusion of acetated Ringer's solution, 25ml/kg over 30min. Blood samples (4ml) were taken every 5min during the first 120min, and thereafter the sampling rate was every 10min until the end of the experiment at 240min. A standard bladder catheter connected to a drip counter to monitor urine excretion continuously was used. The data were analysed by empirical calculations as well as by a mathematical model. Results. Maximum urinary output rate was found to be 19 (13-31) ml/min. The subjects were likely to accumulate three times as much of the infused fluid peripherally as centrally; 1/=2.7 (2.0-5.7). Elimination efficacy, Eeff, was 24 (5-35), and the basal elimination kb was 1.11 (0.28-2.90). The total time delay Ttot of urinary output was estimated as 17 (11-31) min. Conclusion. The experimental results showed a large variability in spite of a homogenous volunteer group. It was possible to compute the infusion amount, plasma dilution and simultaneous urinary output for each consecutive time point and thereby the empirical peripheral fluid accumulation. The variability between individuals may be explained by differences in tissue and hormonal responses to fluid boluses, which needs to be further explored.

LA eng

DO 10.1080/1748670X.2010.494605

LK http://dx.doi.org/10.1080/1748670X.2010.494605

LK http://publications.lib.chalmers.se/records/fulltext/local_130100.pdf

OL 30