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A mechanistic modelling approach to polymer dissolution using magnetic resonance microimaging

E. Kaunisto ; S. Abrahmsen-Alami ; P. Borgquist ; Anette Larsson (Institutionen för kemi- och bioteknik, Farmaceutisk teknologi ; SuMo Biomaterials) ; B. Nilsson ; A. Axelsson
Journal of Controlled Release (0168-3659). Vol. 147 (2010), 2, p. 232-241.
[Artikel, refereegranskad vetenskaplig]

In this paper a computationally efficient mathematical model describing the swelling and dissolution of a polyethylene oxide tablet is presented. The model was calibrated against polymer release, front position and water concentration profile data inside the gel layer, using two different diffusion models. The water concentration profiles were obtained from magnetic resonance microimaging data which, in addition to the previously used texture analysis method, can help to validate and discriminate between the mechanisms of swelling, diffusion and erosion in relation to the dissolution process. Critical parameters were identified through a comprehensive sensitivity analysis, and the effect of hydrodynamic shearing was investigated by using two different stirring rates. Good agreement was obtained between the experimental results and the model. (C) 2010 Elsevier B.V. All rights reserved.

Nyckelord: Dissolution, Polyethylene oxide, MRI, ALE, Mathematical modelling, poly(ethylene oxide), mathematical-models, glassy-polymers, drug-delivery, hpmc matrices, release, reptation, diffusion, rubbery, erosion



Denna post skapades 2010-11-18. Senast ändrad 2016-04-20.
CPL Pubid: 129222

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Farmaceutisk teknologi (2005-2014)
SuMo Biomaterials

Ämnesområden

Kemi

Chalmers infrastruktur