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Systems Biology of Industrial Microorganisms

Marta Papini (Institutionen för kemi- och bioteknik, Systembiologi) ; Margarita Salazar (Institutionen för kemi- och bioteknik, Systembiologi) ; Jens B. Nielsen (Institutionen för kemi- och bioteknik, Systembiologi)
Biosystems Engineering I: Creating Superior Biocatalysts; Book Series: Advances in Biochemical Engineering-Biotechnology (0724-6145 ). Vol. 120 (2010), p. 51-99.
[Artikel, refereegranskad vetenskaplig]

The field of industrial biotechnology is expanding rapidly as the chemical industry is looking towards more sustainable production of chemicals that can be used as fuels or building blocks for production of solvents and materials. In connection with the development of sustainable bioprocesses, it is a major challenge to design and develop efficient cell factories that can ensure cost efficient conversion of the raw material into the chemical of interest. This is achieved through metabolic engineering, where the metabolism of the cell factory is engineered such that there is an efficient conversion of sugars, the typical raw materials in the fermentation industry, into the desired product. However, engineering of cellular metabolism is often challenging due to the complex regulation that has evolved in connection with adaptation of the different microorganisms to their ecological niches. In order to map these regulatory structures and further de-regulate them, as well as identify ingenious metabolic engineering strategies that full-fill mass balance constraints, tools from systems biology can be applied. This involves both high-throughput analysis tools like transcriptome, proteome and metabolome analysis, as well as the use of mathematical modeling to simulate the phenotypes resulting from the different metabolic engineering strategies. It is in fact expected that systems biology may substantially improve the process of cell factory development, and we therefore propose the term Industrial Systems Biology for how systems biology will enhance the development of industrial biotechnology for sustainable chemical production.

Nyckelord: Metabolic engineering, Systems biology, Industrial biotechnology, engineered saccharomyces-cerevisiae, bidirectional reaction steps, fungus aspergillus-fumigatus, tandem mass-spectrometry, complete genome, sequence, metabolic flux analysis, lactic-acid production, yeast, candida-utilis, lipase-encoding gene, human lig4 homolog


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Denna post skapades 2010-11-12. Senast ändrad 2014-10-27.
CPL Pubid: 129009

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Systembiologi (2008-2014)

Ämnesområden

Livsvetenskaper
Industriell bioteknik

Chalmers infrastruktur

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Metabolic Engineering of Central Carbon Metabolism in Saccharomyces cerevisiae The contribution of systems biology to physiological studies