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A regio- and stereo-controlled approach to triazoloquinoxalinyl C-nucleosides

Adel Amer ; Mohammes Salah Ayoup ; Serine N. Khattab ; Seham Y. Hassan ; Vratislav Langer (Institutionen för kemi- och bioteknik, Oorganisk miljökemi) ; Samir Senior ; Abdel Moneim El Massry
Carbohydrate Research (0008-6215). Vol. 345 (2010), 17, p. 2474-2484.
[Artikel, refereegranskad vetenskaplig]

The synthesis of a new series of acyclic triazoloquinoxalinyl C-nucleosides and their transformation to their cyclic analogs are described following protection, activation, and deprotection with subsequent intramolecular nucleophilic substitution protocol. The antibacterial potency of the new compounds was determined using an inhibition zone diameter test. The results show that 3a and 2b exhibit good activity against Escherichia coli and Candida albicans. On the other hand, the cyclic mesylated C-nucleoside 13 showed activity against the Gram-positive bacteria (Staphylococcus aureus) and antifungal activity against C. albicans.

Nyckelord: Acyclic triazoloquinoxalinyl C-nucleosides, Cyclic triazoloquinoxalinyl C-nucleosides, Antimicrobial activity, Tautomerism



Denna post skapades 2010-10-28. Senast ändrad 2010-12-20.
CPL Pubid: 128290

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Oorganisk miljökemi (2005-2014)

Ämnesområden

Organisk syntes
Läkemedelskemi

Chalmers infrastruktur