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Non-coding RNAs and a layered architecture of genetic networks

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik)
Central European Journal of Physics (1895-1082). Vol. 8 (2010), 6, p. 864-872.
[Artikel, refereegranskad vetenskaplig]

In eukaryotic cells, protein-coding sequences constitute a relatively small part of the genome. The rest of the genome is transcribed to non-coding RNAs (ncRNAs). Such RNAs form the cornerstone of a regulatory network that operates in parallel with the protein network. Their biological functions are based primarily on the ability to pair with and deactivate target messenger RNAs (mRNAs). To clarify the likely role of ncRNAs in complex genetic networks, we present and comprehensively analyze a kinetic model of one of the key counterparts of the network architectures. Specifically, the genes transcribed to ncRNAs are considered to interplay with a hierarchical two-layer set of genes transcribed to mRNAs. The genes forming the bottom layer are regulated from the top and negatively self-regulated. If the former regulation is positive, the dependence of the RNA populations on the governing parameters is found to be often non-monotonous. Specifically, the model predicts bistability. If the regulation is negative, the dependence of the RNA populations on the governing parameters is monotonous. In particular, the population of the mRNAs, corresponding to the genes forming the bottom layer, is nearly constant.

Nyckelord: subcellular processes, mRNA and ncRNA synthesis, degradation and, association, nonlinear dynamics, mean-field kinetic equations, bistability, transcriptional regulatory network, distinct messenger-rnas, nonprotein, coding rna, escherichia-coli, expression, micrornas, dynamics, protein, biology, models

Denna post skapades 2010-10-28. Senast ändrad 2012-02-22.
CPL Pubid: 128283


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Institutionen för teknisk fysik, Kemisk fysik (1900-2015)



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