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Adsorption of proteins on a lipid bilayer

Vladimir P. Zhdanov (Institutionen för teknisk fysik, Kemisk fysik) ; Bengt Kasemo (Institutionen för teknisk fysik, Kemisk fysik)
European Biophysics Journal with Biophysics Letters (0175-7571). Vol. 39 (2010), 11, p. 1477-1482.
[Artikel, refereegranskad vetenskaplig]

In our analysis of protein adsorption on a lipid bilayer, the protein surface is considered to contain one or a few charged spots, and the bilayer contains a significant amount of lipids with oppositely charged head groups. After adsorption, a folded protein is assumed to change its shape slightly due to the electrostatic attraction, so that one of the spots forms a flat contact with the oppositely charged lipid heads of the lipid bilayer. With realistic parameters, this model predicts that the contribution of electrostatic interactions to the protein adsorption energy per charged amino acid-lipid pair is 16-25 kJ/mol. Thus, a few (four or five) pairs is sufficient for irreversible adsorption.

Nyckelord: Proteins, Lipids, Adsorption energy, Electrostatic interactions, Poisson-Boltzmann equation, atomic-force microscopy, monte-carlo simulations, marcks-related, protein, charged macromolecules, solid-surfaces, qcm-d, membranes, binding, afm

Denna post skapades 2010-10-14. Senast ändrad 2014-03-24.
CPL Pubid: 127607


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