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Leukocyte oxygen radical production determines disease severity in the recurrent Guillain-Barré

Natalia Mossberg ; Oluf Andersen ; Magnus Nordin ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Åke Svedhem ; Tomas Bergström ; Kristoffer Hellstrand ; Charlotta Movitz
Journal of Inflammation (1476-9255). Vol. 7 (2010), p. Art nr. 40.
[Artikel, refereegranskad vetenskaplig]

Background: The recurrent Guillain-Barré syndrome (RGBS) is characterized by at least two GBS episodes with intervening remission. In a previous study of monophasic GBS, we reported that the magnitude of oxygen radical production ("respiratory burst”) in peripheral blood leukocytes was inversely correlated to disease severity. The present study sought to establish a similar correlation in patients with RGBS. Methods: Oxygen radical production in leukocytes was induced by formyl-Met-Leu-Phe (fMLF), Trp-Lys-Tyr-Met-Val- Met-NH2 (WKYMVM), or phorbol myristate acetate (PMA) and assessed by quantifying superoxide anion formed by the leukocyte NADPH oxidase. Results: Disease severity, assessed using the MRC score, was negatively correlated to superoxide anion production triggered by fMLF or WKYMVM (p = 0.001 and 0.002, respectively; n = 10). Superoxide anion production also was significantly lower in RGBS patients with incomplete recovery after stimulation with fMLF (p = 0.004) or WKYMVM (p = 0.003). Conclusion: We conclude that a lower respiratory burst in leukocytes is strongly associated with a severe course of RGBS

Nyckelord: oxygen radical production, RGBS, severity

Denna post skapades 2010-08-20. Senast ändrad 2016-06-29.
CPL Pubid: 124986


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Institutionen för neurovetenskap och fysiologi (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för biomedicin (GU)


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