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Analytical approaches to investigate transmitter content and release from single secretory vesicles

Donna Omiatek ; Ann-Sofie Cans (Institutionen för kemi- och bioteknik, Fysikalisk kemi) ; Michael Heien ; Andrew G Ewing
Analytical and Bioanalytical Chemistry (1618-2642 ). Vol. 397 (2010), 8, p. 3269-3279.
[Artikel, refereegranskad vetenskaplig]

The vesicle serves as the primary intracellular unit for the highly efficient storage and release of chemical messengers triggered during signaling processes in the nervous system. This review highlights conventional and emerging analytical methods that have used microscopy, electrochemistry, and spectroscopy to resolve the location, time course, and quantal content characteristics of neurotransmitter release. Particular focus is on the investigation of the synaptic vesicle and its involvement in the fundamental molecular mechanisms of cell communication.

Nyckelord: Vesicle . Exocytosis . Neurotransmitter . Carbon-fiber amperometry . Electrochemical cytometry. Capillary electrophoresis



Denna post skapades 2010-08-17. Senast ändrad 2015-02-26.
CPL Pubid: 124656

 

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Institutioner (Chalmers)

Institutionen för kemi- och bioteknik, Fysikalisk kemi (2005-2014)
Institutionen för kemi (2001-2011)

Ämnesområden

Analytisk kemi
Separationsmetoder
Elektrokemi
Neurokemi

Chalmers infrastruktur