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Searching for genes influencing a complex disease: the case of coeliac disease.

Åsa Torinsson Naluai ; Henry Ascher ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Jan Wahlström
European journal of human genetics : EJHG (1018-4813). Vol. 16 (2008), 5, p. 542-53.
[Artikel, refereegranskad vetenskaplig]

Recently, a few genes have been reported to be causative in inflammatory diseases. Still, we are waiting for the vast majority to be discovered. New tools for genotyping and statistical analysis have been developed and emphasis has been put on study design. Coeliac disease (CD) is a disorder, where prolamins in dietary wheat gluten and related proteins from rye or barley are not tolerated. It is one of the most common chronic diseases in humans exceeding a population prevalence of 1%. In this article, we will summarise what is currently known about the genetics influencing CD with the emphasis on the non-HLA genetic component. We will discuss some difficulties when searching for susceptibility genes in disorders with complex inheritance patterns.

Nyckelord: Celiac Disease, epidemiology, genetics, Evolution, Genetic Predisposition to Disease, Genetics, Population, Humans, Linkage (Genetics), Phenotype

Denna post skapades 2010-06-04. Senast ändrad 2015-12-09.
CPL Pubid: 122359


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Institutioner (Chalmers)

Institutionen för cell- och molekylärbiologi (1994-2011)
Institutionen för kliniska vetenskaper, sektionen för kvinnors och barns hälsa (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för cell- och molekylärbiologi, genetik (1994-2011)


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