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Sealing of Submicrometer Wells by a Shear-Driven Lipid Bilayer

Peter Jönsson (Institutionen för teknisk fysik, Biologisk fysik) ; Magnus Jonsson (Institutionen för teknisk fysik, Biologisk fysik) ; Fredrik Höök (Institutionen för teknisk fysik, Biologisk fysik)
Nano Letters (1530-6984). Vol. 10 (2010), 5, p. 1900-1906.
[Artikel, refereegranskad vetenskaplig]

A supported lipid bilayer (SLB) was formed in a microfluidic channel by vesicle fusion. The SLB, formed on a flat part of the surface, was driven by the shear forces of a bulk flow above the SLB to a part of the surface with embedded submicrometer wells. When using a bulk solution with a pH of 9.5 the advancing lipid bilayer sealed the wells, creating free-spanning membranes, whereas at a pH of 8.0 the SLB instead followed the contour of the wells.

Nyckelord: Spreading lipid bilayers, black lipid membranes, microfluidics, molecule encapsulation, nanostructures, SUPPORTED PHOSPHOLIPID-BILAYERS, HYDROPHILIC SURFACES, NANOPORE ARRAYS, MEMBRANES, DIFFUSION, SILICON, MONOLAYERS, BIOSENSOR, KINETICS, CHANNELS

Denna post skapades 2010-05-28.
CPL Pubid: 122026


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Institutionen för teknisk fysik, Biologisk fysik (2007-2015)



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Properties and Applications of Shear-Driven Lipid Bilayers