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Associations between the angiotensin-converting enzyme insertion/deletion polymorphism and monoamine metabolite concentrations in cerebrospinal fluid.

Kristina Annerbrink ; Erik G Jönsson ; Marie Olsson ; Staffan Nilsson (Institutionen för matematiska vetenskaper, matematisk statistik) ; Göran C Sedvall ; Henrik Anckarsäter ; Elias Eriksson
Psychiatry research (0165-1781). Vol. 179 (2010), 2, p. 231-234.
[Artikel, refereegranskad vetenskaplig]

Angiotensin II has been suggested to influence central dopamine and serotonin turnover. Since the angiotensin-converting enzyme (ACE) plays a key role in angiotensin regulation by converting inactive angiotensin I to active angiotensin II, we hypothesised that the functional insertion/deletion (I/D) polymorphism in the ACE gene, which has previously been suggested to be associated with, depression and panic disorder, may influence monoamine activity. A well-established technique for assessing brain monoamine turnover in humans is to measure concentrations of monoamine metabolites in the cerebrospinal fluid (CSF). We thus investigated possible associations between the ACE I/D polymorphism and CSF monoamine metabolite concentrations in a population of healthy male subjects. After having found such an association between the ACE I/D polymorphism and CSF levels of the dopamine metabolite homovanillic acid and the serotonin metabolite 5-hydroxyindoleacetic acid in this sample, I carriers displaying lower levels, we tried to replicate this observation in a population of violent male offenders from which also both CSF and DNA were available. Also in this sample, the same associations were found. Our results suggest that the ACE I/D polymorphism may play a role in the modulation of serotonergic and dopaminergic turnover in men.



Denna post skapades 2010-05-26. Senast ändrad 2015-01-16.
CPL Pubid: 121897

 

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Institutioner (Chalmers)

Institutionen för neurovetenskap och fysiologi, sektionen för farmakologi (GU)
Institutionen för matematiska vetenskaper, matematisk statistik (2005-2016)
Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi (GU)

Ämnesområden

MEDICIN OCH HÄLSOVETENSKAP

Chalmers infrastruktur