CPL - Chalmers Publication Library
| Utbildning | Forskning | Styrkeområden | Om Chalmers | In English In English Ej inloggad.

Formation of geometrically complex lipid nanotube-vesicle networks of higher-order topologies

M. Karlsson ; Kristin Sott ; M. Davidson ; A. S. Cans ; P. Linderholm ; D. Chiu ; Owe Orwar (Institutionen för fysikalisk kemi)
Proc Natl Acad Sci U S A (0027-8424 (Print) 0027-8424 (Linking)). Vol. 99 (2002), 18, p. 11573-8.
[Artikel, refereegranskad vetenskaplig]

We present a microelectrofusion method for construction of fluid-state lipid bilayer networks of high geometrical complexity up to fully connected networks with genus = 3 topology. Within networks, self-organizing branching nanotube architectures could be produced where intersections spontaneously arrange themselves into three-way junctions with an angle of 120 degrees between each nanotube. Formation of branching nanotube networks appears to follow a minimum-bending energy algorithm that solves for pathway minimization. It is also demonstrated that materials can be injected into specific containers within a network by nanotube-mediated transport of satellite vesicles having defined contents. Using a combination of microelectrofusion, spontaneous nanotube pattern formation, and satellite-vesicle injection, complex networks of containers and nanotubes can be produced for a range of applications in, for example, nanofluidics and artificial cell design. In addition, this electrofusion method allows integration of biological cells into lipid nanotube-vesicle networks.

Nyckelord: Lipids/*chemistry, Microscopy, Fluorescence, Molecular Structure



Denna post skapades 2010-03-01. Senast ändrad 2010-04-30.
CPL Pubid: 116799

 

Läs direkt!


Länk till annan sajt (kan kräva inloggning)


Institutioner (Chalmers)

Institutionen för fysik (GU) (GU)
Institutionen för fysikalisk kemi (1900-2003)

Ämnesområden

Kemi

Chalmers infrastruktur